Sustained Interleukin-1β Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids

Clinical treatment with glucocorticoids (GC) can be complicated by cytokine-induced glucocorticoid low-responsiveness (GC-resistance, GCR), a condition associated with a homogeneous reduction in the expression of GC-receptor- (GR-) driven anti-inflammatory genes. However, GR level and phosphorylatio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Escoll, Pedro, Ranz, Ismael, Muñoz-Antón, Norman, van-den-Rym, Ana, Alvarez-Mon, Melchor, Martínez-Alonso, Carlos, Sanz, Eva, de-la-Hera, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421076/
https://ncbi.nlm.nih.gov/pubmed/25977599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/347965
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados