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Prediction of distal residue participation in enzyme catalysis

A scoring method for the prediction of catalytically important residues in enzyme structures is presented and used to examine the participation of distal residues in enzyme catalysis. Scores are based on the Partial Order Optimum Likelihood (POOL) machine learning method, using computed electrostati...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Brodkin, Heather R, DeLateur, Nicholas A, Somarowthu, Srinivas, Mills, Caitlyn L, Novak, Walter R, Beuning, Penny J, Ringe, Dagmar, Ondrechen, Mary Jo
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420525/
https://ncbi.nlm.nih.gov/pubmed/25627867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2648
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