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Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia
Aberrant activation of the Wnt pathway plays a pathogenetic role in tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). Lymphoid enhancer binding factor 1 (LEF1), a key mediator of Wnt signaling, has been linked to leukemic transformation, and LEF1 mutations ha...
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| Publicado en: | PLoS One |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4420493/ https://ncbi.nlm.nih.gov/pubmed/25942645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125429 |
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