Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms

Parathyroid Hormone (PTH) can exert both anabolic and catabolic effects on the skeleton, potentially through expression of the PTH type1 receptor (PTH1R), which is highly expressed in osteocytes. To determine the cellular and molecular mechanisms responsible, we examined the effects of PTH on osteob...

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Veröffentlicht in:PLoS One
Hauptverfasser: Prideaux, Matthew, Dallas, Sarah L., Zhao, Ning, Johnsrud, Erica D., Veno, Patricia A., Guo, Dayong, Mishina, Yuji, Harris, Stephen E., Bonewald, Lynda F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420268/
https://ncbi.nlm.nih.gov/pubmed/25942444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125731
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