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Synthesis of Two New Enrichable and MS-Cleavable Cross-linkers to Define Protein-Protein Interactions by Mass Spectrometry

The cross-linking Mass Spectrometry (XL-MS) technique extracts structural information from protein complexes without requiring highly purified samples, crystallinity, or large amounts of material. However, there are challenges to applying the technique to protein complexes in vitro, and those challe...

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Bibliografiske detaljer
Udgivet i:Org Biomol Chem
Main Authors: Burke, Anthony M., Kandur, Wynne, Novitsky, Eric J., Kaake, Robyn M., Yu, Clinton, Kao, Athit, Vellucci, Danielle, Huang, Lan, Rychnovsky, Scott D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4420144/
https://ncbi.nlm.nih.gov/pubmed/25823605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob00488h
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