Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer’s disease

GluN2B subunit containing NMDARs (GluN2B-NMDARs) mediate pathophysiological effects of acutely applied amyloid beta (Aβ), including impaired long-term potentiation (LTP). However, in transgenic Alzheimer’s disease (AD) mouse models which feature gradual Aβ accumulation, the function of GluN2B-NMDARs...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Hanson, Jesse E., Pare, Jean-Francois, Deng, Lunbin, Smith, Yoland, Zhou, Qiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419865/
https://ncbi.nlm.nih.gov/pubmed/25484285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.11.017
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