Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling

BACKGROUND: Osteosarcoma (OS) is the most common type of solid bone cancer, with latent metastasis being a typical mode of disease progression and a major contributor to poor prognosis. For this to occur, cells must resist anoikis and be able to recapitulate tumorigenesis in a foreign microenvironme...

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Veröffentlicht in:J Transl Med
Hauptverfasser: Foley, Jessica M, Scholten II, Donald J, Monks, Noel R, Cherba, David, Monsma, David J, Davidson, Paula, Dylewski, Dawna, Dykema, Karl, Winn, Mary E, Steensma, Matthew R
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419490/
https://ncbi.nlm.nih.gov/pubmed/25889105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0466-4
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