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Secreted CXCL12 (SDF-1) Forms Dimers under Physiologic Conditions

Chemokine CXCL12 signaling through receptors CXCR4 and CXCR7 has essential functions in development and underlies diseases including cancer, atherosclerosis, and autoimmunity. Chemokines may form homodimers that regulate receptor binding and signaling, but previous studies with synthetic CXCL12 have...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Ray, Paramita, Lewin, Sarah A., Mihalko, Laura Anne, Lesher-Perez, Sasha Cai, Takayama, Shuichi, Luker, Kathryn E., Luker, Gary D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4419379/
https://ncbi.nlm.nih.gov/pubmed/22142194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111341
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