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3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways

Oxygen status and tissue dimensionality are critical determinants of tumor angiogenesis, a hallmark of cancer and an enduring target for therapeutic intervention. However, it is unclear how these microenvironmental conditions interact to promote neovascularization, due in part to a lack of comprehen...

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Vydáno v:Biomaterials
Hlavní autoři: DelNero, Peter, Lane, Maureen, Verbridge, Scott S., Kwee, Brian, Kermani, Pouneh, Hempstead, Barbara, Stroock, Abraham, Fischbach, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417672/
https://ncbi.nlm.nih.gov/pubmed/25934456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.03.035
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