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T cell-associated α(4)β(7) but not α(4)β(1) integrin is required for the induction and perpetuation of chronic colitis
Anti-adhesion therapies that target α(4) integrins (e.g., natalizumab) are thought to work by blocking T-cell recruitment to the intestinal tissues in patients with Crohn’s disease (CD); however, little direct evidence is available to confirm this contention. We wished to evaluate the importance of...
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| Publicado no: | Mucosal Immunol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4417258/ https://ncbi.nlm.nih.gov/pubmed/24717354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.22 |
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