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Increased Sensitivity to Noise-Induced Hearing Loss by Blockade of Endogenous PI3K/Akt Signaling

The PI3K/Akt signaling pathway is involved in mediating survival of sensory hair cells. Here, we investigated the involvement of PI3K/Akt in noise-induced hearing loss in both temporary and permanent threshold shift noise models. The PI3K regulatory subunit p85α and phosphorylation of Akt on serine...

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Detalhes bibliográficos
Publicado no:J Assoc Res Otolaryngol
Main Authors: Chen, Jun, Yuan, Hu, Talaska, Andra E., Hill, Kayla, Sha, Su-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417093/
https://ncbi.nlm.nih.gov/pubmed/25790950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10162-015-0508-x
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