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Heat Shock Inhibition of CDK5 Increases NOXA Levels through miR-23a Repression

Hyperthermia is a proteotoxic stress that is lethal when exposure is extreme but also cytoprotective in that sublethal exposure leads to the synthesis of heat shock proteins, including HSP70, which are able to inhibit stress-induced apoptosis. CDK5 is an atypical cyclin-dependent kinase family membe...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Morey, Trevor M., Roufayel, Rabih, Johnston, Donald S., Fletcher, Andrew S., Mosser, Dick D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416849/
https://ncbi.nlm.nih.gov/pubmed/25829494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625988
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