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Structural Basis for Competitive Inhibition of 3,4-Dihydroxy-2-butanone-4-phosphate Synthase from Vibrio cholerae

The riboflavin biosynthesis pathway has been shown to be essential in many pathogens and is absent in humans. Therefore, enzymes involved in riboflavin synthesis are considered as potential antibacterial drug targets. The enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBPS) catalyzes one of...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Islam, Zeyaul, Kumar, Adarsh, Singh, Suruchi, Salmon, Laurent, Karthikeyan, Subramanian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416836/
https://ncbi.nlm.nih.gov/pubmed/25792735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611830
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