Discovery of Benzimidazole Oxazolidinediones as Novel and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

[Image: see text] Elaboration of the oxazolidinedione series led to replacement of the exocyclic amides with substituted benzimidazoles. The structure–activity relationship (SAR) exploration resulted in the discovery of potent and selective nonsteroidal mineralocorticoid receptor (MR) antagonists wi...

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Gepubliceerd in:ACS Med Chem Lett
Hoofdauteurs: Yang, Christine, Balsells, Jaume, Chu, Hong D., Cox, Jason M., Crespo, Alejandro, Ma, Xiuying, Contino, Lisa, Brown, Patricia, Gao, Sheng, Zamlynny, Beata, Wiltsie, Judyann, Clemas, Joseph, Lisnock, JeanMarie, Gibson, Jack, Zhou, Gaochao, Garcia-Calvo, Margarita, Bateman, Thomas J., Tong, Vincent, Xu, Ling, Crook, Martin, Sinclair, Peter, Shen, Hong C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2015
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416436/
https://ncbi.nlm.nih.gov/pubmed/25941555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00010
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