Discovery of Benzimidazole Oxazolidinediones as Novel and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

[Image: see text] Elaboration of the oxazolidinedione series led to replacement of the exocyclic amides with substituted benzimidazoles. The structure–activity relationship (SAR) exploration resulted in the discovery of potent and selective nonsteroidal mineralocorticoid receptor (MR) antagonists wi...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Yang, Christine, Balsells, Jaume, Chu, Hong D., Cox, Jason M., Crespo, Alejandro, Ma, Xiuying, Contino, Lisa, Brown, Patricia, Gao, Sheng, Zamlynny, Beata, Wiltsie, Judyann, Clemas, Joseph, Lisnock, JeanMarie, Gibson, Jack, Zhou, Gaochao, Garcia-Calvo, Margarita, Bateman, Thomas J., Tong, Vincent, Xu, Ling, Crook, Martin, Sinclair, Peter, Shen, Hong C.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416436/
https://ncbi.nlm.nih.gov/pubmed/25941555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00010
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items