Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis

BACKGROUND: Malignant peripheral nerve sheath tumor (MPNST) is a rare and highly aggressive disease with no evidence of effect from adjuvant therapy. It is further associated with the hereditary syndrome neurofibromatosis type 1 (NF1). Silencing of the tumor suppressor gene RASSF1A through DNA promo...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Danielsen, Stine A., Lind, Guro E., Kolberg, Matthias, Høland, Maren, Bjerkehagen, Bodil, Sundby Hall, Kirsten, van den Berg, Eva, Mertens, Fredrik, Smeland, Sigbjørn, Picci, Piero, Lothe, Ragnhild A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416132/
https://ncbi.nlm.nih.gov/pubmed/25038505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou140
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