Diffusion and Swelling Measurements in Pharmaceutical Powder Compacts Using Terahertz Pulsed Imaging

Tablet dissolution is strongly affected by swelling and solvent penetration into its matrix. A terahertz-pulsed imaging (TPI) technique, in reflection mode, is introduced as a new tool to measure one-dimensional swelling and solvent ingress in flat-faced pharmaceutical compacts exposed to dissolutio...

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Bibliographic Details
Published in:J Pharm Sci
Main Authors: Yassin, Samy, Su, Ke, Lin, Hungyen, Gladden, Lynn F, Zeitler, J Axel
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
Subjects:
Pharmaceutics, Drug Delivery and Pharmaceutical Technology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415463/
https://ncbi.nlm.nih.gov/pubmed/25645509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24376
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