PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects

The protein phosphatase 2A (PP2A) is a key tumor suppressor which has emerged as a novel molecular target in some human cancers. Here, we show that PP2A inhibition is a common event in breast cancer and identified PP2A phosphorylation and deregulation SET and CIP2A as molecular contributing mechanis...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Rincón, Raúl, Cristóbal, Ion, Zazo, Sandra, Arpí, Oriol, Menéndez, Silvia, Manso, Rebeca, Lluch, Ana, Eroles, Pilar, Rovira, Ana, Albanell, Joan, García-Foncillas, Jesús, Madoz-Gúrpide, Juan, Rojo, Federico
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414191/
https://ncbi.nlm.nih.gov/pubmed/25726524
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