Morphine promotes cancer stem cell properties, contributing to chemoresistance in breast cancer

Morphine is an opioid analgesic drug commonly used for pain relief in cancer patients. Here, we report that morphine enhances the mammosphere forming capacity and increases the expression of stemness-related transcription factors Oct4, Sox2 and Nanog. Treatment with morphine leads to enrichment of a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Niu, Dong-Ge, Peng, Fei, Zhang, Wei, Guan, Zhong, Zhao, Hai-Dong, Li, Jing-Lin, Wang, Kai-Li, Li, Ting-Ting, Zhang, Yan, Zheng, Fei-Meng, Xu, Fan, Han, Qian-Ni, Gao, Peng, Wen, Qing-Ping, Liu, Quentin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4414166/
https://ncbi.nlm.nih.gov/pubmed/25686831
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