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Frameshift mutations at two hotspots in vasopressin transcripts in post-mitotic neurons.

Mutations in DNA underlie carcinogenesis, inherited pathology, and aging and are generally thought to be introduced during meiosis and mitosis. Here we report that in post-mitotic neurons specific frameshift mutations occur at high frequency. These mutations were identified in vasopressin transcript...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Evans, D A, van der Kleij, A A, Sonnemans, M A, Burbach, J P, van Leeuwen, F W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44137/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8016115/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.13.6059
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