A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation

We recently identified an endomembrane-based signalling cascade that is activated by the KDEL receptor (KDELR) on the Golgi complex. At the Golgi, the KDELR acts as a traffic sensor (presumably via binding to chaperones that leave the ER) and triggers signalling pathways that balance membrane fluxes...

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Udgivet i:Oncotarget
Main Authors: Ruggiero, Carmen, Fragassi, Giorgia, Grossi, Mauro, Picciani, Benedetta, Di Martino, Rosaria, Capitani, Mirco, Buccione, Roberto, Luini, Alberto, Sallese, Michele
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413660/
https://ncbi.nlm.nih.gov/pubmed/25682866
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