Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells

Oncolytic adenovirus and apoptosis inducer TRAIL are promising cancer therapies. Their antitumor efficacy, when used as single agents, is limited. Oncolytic adenoviruses have low infection activity, and cancer cells develop resistance to TRAIL-induced apoptosis. Here, we explored combining prostate-...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Liu, Youhong, Chen, Lin, Gong, Zhicheng, Shen, Liangfang, Kao, Chinghai, Hock, Janet M., Sun, Lunquan, Li, Xiong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413637/
https://ncbi.nlm.nih.gov/pubmed/25605010
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