Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells

Oncolytic adenovirus and apoptosis inducer TRAIL are promising cancer therapies. Their antitumor efficacy, when used as single agents, is limited. Oncolytic adenoviruses have low infection activity, and cancer cells develop resistance to TRAIL-induced apoptosis. Here, we explored combining prostate-...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Liu, Youhong, Chen, Lin, Gong, Zhicheng, Shen, Liangfang, Kao, Chinghai, Hock, Janet M., Sun, Lunquan, Li, Xiong
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2014
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413637/
https://ncbi.nlm.nih.gov/pubmed/25605010
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