Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice

Functional adaptation may complicate the choice of phenotype used in genetic studies that seek to identify genes contributing to fracture susceptibility. Often, genetic variants affecting one trait are compensated by coordinated changes in other traits. Bone fracture is a prototypic example because...

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Detaylı Bibliyografya
Yayımlandı:Bone
Asıl Yazarlar: Smith, Lauren M., Bigelow, Erin M.R., Nolan, Bonnie T., Faillace, Meghan E., Nadeau, Joseph H., Jepsen, Karl J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413452/
https://ncbi.nlm.nih.gov/pubmed/25003813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.06.035
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