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Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice
Functional adaptation may complicate the choice of phenotype used in genetic studies that seek to identify genes contributing to fracture susceptibility. Often, genetic variants affecting one trait are compensated by coordinated changes in other traits. Bone fracture is a prototypic example because...
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| Veröffentlicht in: | Bone |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413452/ https://ncbi.nlm.nih.gov/pubmed/25003813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2014.06.035 |
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