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Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile

One of the most important functions of the opioid system is the control of pain. Among the three main opioid receptor classes (μ, δ, κ), the μ (MOR) is the main type targeted for pharmacotherapy of pain. Opioid analgesics such as morphine, oxycodone and fentanyl are agonists at the MOR and are the m...

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Bibliografski detalji
Izdano u:Int J Med Chem
Glavni autori: Schmidhammer, Helmut, Spetea, Mariana
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4412049/
https://ncbi.nlm.nih.gov/pubmed/25954525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/208039
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