Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas

BACKGROUND: Rb1 is the most frequently mutated gene in the pediatric cancer retinoblastoma, and its loss causes E2F transcription factors to induce proliferation related genes. However, high E2F levels following pRB loss also induce apoptosis-promoting genes as a safeguard mechanism to suppress emer...

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Bibliografiska uppgifter
I publikationen:Mol Cancer
Huvudupphovsmän: Xie, Chencheng, Lu, Huarui, Nomura, Alice, Hanse, Eric Allan, Forster, Colleen Lynn, Parker, Josh Berken, Linden, Michael Andrew, Karasch, Chris, Hallstrom, Timothy Curtis
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2015
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411757/
https://ncbi.nlm.nih.gov/pubmed/25907958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0360-y
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