Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors

INTRODUCTION: Autoantibodies contribute significantly to the pathogenesis of systemic lupus erythematosus (SLE). Unfortunately, the long-lived plasma cells (LLPCs) secreting such autoantibodies are refractory to conventional immunosuppressive treatments. Although generated long before the disease be...

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Udgivet i:Arthritis Res Ther
Main Authors: Taddeo, Adriano, Khodadadi, Laleh, Voigt, Caroline, Mumtaz, Imtiaz M, Cheng, Qingyu, Moser, Katrin, Alexander, Tobias, Manz, Rudolf A, Radbruch, Andreas, Hiepe, Falk, Hoyer, Bimba F
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411657/
https://ncbi.nlm.nih.gov/pubmed/25889236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0551-3
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