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Guanylyl Cyclases A and B Are Asymmetric Dimers That Are Allosterically Activated by ATP Binding to the Catalytic Domain

It is not known how natriuretic peptides and adenosine triphosphate (ATP) activate guanylyl cyclase A (GC-A) and GC-B, which generate the second messenger cyclic guanosine monophosphate. We determined that natriuretic peptides increased the maximum rate of these enzymes >10-fold in a positive coo...

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Bibliografiske detaljer
Udgivet i:Sci Signal
Main Authors: Robinson, Jerid W., Potter, Lincoln R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411398/
https://ncbi.nlm.nih.gov/pubmed/22949736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003253
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