Expression of Sirtuin 1 and 2 Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer Patients

BACKGROUND: Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes. In this study we evaluated the relevance of these deacetylases in lung cancer biology. MATERIAL AND METHODS: Protein levels of SIRT1 and SIRT2 were d...

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Vydáno v:PLoS One
Hlavní autoři: Grbesa, Ivana, Pajares, María J., Martínez-Terroba, Elena, Agorreta, Jackeline, Mikecin, Ana-Matea, Larráyoz, Marta, Idoate, Miguel A., Gall-Troselj, Koraljka, Pio, Ruben, Montuenga, Luis M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411155/
https://ncbi.nlm.nih.gov/pubmed/25915617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124670
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