ESAT-6 Targeting to DEC205+ Antigen Presenting Cells Induces Specific-T Cell Responses against ESAT-6 and Reduces Pulmonary Infection with Virulent Mycobacterium tuberculosis

Airways infection with Mycobacterium tuberculosis (Mtb) is contained mostly by T cell responses, however, Mtb has developed evasion mechanisms which affect antigen presenting cell (APC) maturation/recruitment delaying the onset of Ag-specific T cell responses. Hypothetically, bypassing the natural i...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Silva-Sánchez, Aarón, Meza-Pérez, Selene, Flores-Langarica, Adriana, Donis-Maturano, Luis, Estrada-García, Iris, Calderón-Amador, Juana, Hernández-Pando, Rogelio, Idoyaga, Juliana, Steinman, Ralph M., Flores-Romo, Leopoldo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4411092/
https://ncbi.nlm.nih.gov/pubmed/25915045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124828
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