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VarSim: a high-fidelity simulation and validation framework for high-throughput genome sequencing with cancer applications

Summary: VarSim is a framework for assessing alignment and variant calling accuracy in high-throughput genome sequencing through simulation or real data. In contrast to simulating a random mutation spectrum, it synthesizes diploid genomes with germline and somatic mutations based on a realistic mode...

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Bibliografski detalji
Izdano u:Bioinformatics
Glavni autori: Mu, John C., Mohiyuddin, Marghoob, Li, Jian, Bani Asadi, Narges, Gerstein, Mark B., Abyzov, Alexej, Wong, Wing H., Lam, Hugo Y.K.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4410653/
https://ncbi.nlm.nih.gov/pubmed/25524895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu828
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