Seven novel modulators of the analgesic target Na(V) 1.7 uncovered using a high-throughput venom-based discovery approach

BACKGROUND AND PURPOSE: Chronic pain is a serious worldwide health issue, with current analgesics having limited efficacy and dose-limiting side effects. Humans with loss-of-function mutations in the voltage-gated sodium channel Na(V)1.7 (hNa(V)1.7) are indifferent to pain, making hNa(V)1.7 a promis...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Klint, Julie K, Smith, Jennifer J, Vetter, Irina, Rupasinghe, Darshani B, Er, Sing Yan, Senff, Sebastian, Herzig, Volker, Mobli, Mehdi, Lewis, Richard J, Bosmans, Frank, King, Glenn F
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409898/
https://ncbi.nlm.nih.gov/pubmed/25754331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13081
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