The Androgen-Regulated Protease TMPRSS2 Activates aProteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Lucas, Jared M., Heinlein, Cynthia, Kim, Tom, Hernandez, Susana A., Malik, Muzdah S., True, Lawrence D., Morrissey, Colm, Corey, Eva, Montgomery, Bruce, Mostaghel, Elahe, Clegg, Nigel, Coleman, Ilsa, Brown, Christopher M., Schneider, Eric L., Craik, Charles, Simon, Julian, Bedalov, Tony, Nelson, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409786/
https://ncbi.nlm.nih.gov/pubmed/25122198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-1010
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