SLAMF4 is a Negative Regulator of Expansion of Cytotoxic Intra-epithelial CD8+ T Cells That Maintains Homeostasis in the Small Intestine

BACKGROUND & AIMS: Intra-epithelial T cells (IEL) are the first immune cells to respond to pathogens; they help maintain the integrity of the epithelial barrier. We studied the function of the glycoprotein SLAMF4 (encoded by CD244) on the surface of CD8αβ αβ T-cell receptor (TCR)(+) IELs, and th...

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Udgivet i:Gastroenterology
Main Authors: O’Keeffe, Michael S., Song, Joo-Hye, Liao, Gongxian, De Calisto, Jaime, Halibozek, Peter J., Mora, J. Rodrigo, Bhan, Atul K., Wang, Ninghai, Reinecker, Hans-Christian, Terhorst, Cox
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409516/
https://ncbi.nlm.nih.gov/pubmed/25678452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2015.02.003
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