The Effect of Protease Inhibitors on the Induction of Osteoarthritis-Related Biomarkers in Bovine Full-Depth Cartilage Explants

OBJECTIVE: The specific degradation of type II collagen and aggrecan by matrix metalloproteinase (MMP)-9, -13 and ADAMTS-4 and -5 (aggrecanase-1 and -2) in the cartilage matrix is a critical step in pathology of osteoarthritis (OA). The aims of this study were: i) To investigate the relative contrib...

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Publicado en:PLoS One
Main Authors: He, Yi, Zheng, Qinlong, Jiang, MengMeng, Sun, Shu, Christiansen, Thorbjørn G., Kassem, Moustapha, Karsdal, Morten A., Bay-Jensen, Anne C.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409205/
https://ncbi.nlm.nih.gov/pubmed/25909781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122700
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