The Anti-Inflammatory Activity of a Novel Fused-Cyclopentenone Phosphonate and Its Potential in the Local Treatment of Experimental Colitis

A novel fused-cyclopentenone phosphonate compound, namely, diethyl 3-nonyl-5-oxo-3,5,6,6a-tetrahydro-1H-cyclopenta[c]furan-4-ylphosphonate (P-5), was prepared and tested in vitro (LPS-activated macrophages) for its cytotoxicity and anti-inflammatory activity and in vivo (DNBS induced rat model) for...

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Veröffentlicht in:Gastroenterol Res Pract
Hauptverfasser: Moradov, Dorit, Shifrin, Helena, Harel, Efrat, Nadler-Milbauer, Mirela, Weinstock, Marta, Srebnik, Morris, Rubinstein, Abraham
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408640/
https://ncbi.nlm.nih.gov/pubmed/25949237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/939483
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