Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation

Increased plasma branched-chain amino acid concentrations are associated with insulin resistance, and intravenous amino acid infusion blunts insulin-mediated glucose disposal. We tested the hypothesis that protein ingestion impairs insulin-mediated glucose disposal by leucine-mediated mTOR signaling...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Smith, Gordon I., Yoshino, Jun, Stromsdorfer, Kelly L., Klein, Seth J., Magkos, Faidon, Reeds, Dominic N., Klein, Samuel, Mittendorfer, Bettina
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407849/
https://ncbi.nlm.nih.gov/pubmed/25475435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1279
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