Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

BACKGROUND: Artemether-lumefantrine (AL) dispersible formulation was developed for the treatment of uncomplicated Plasmodium falciparum malaria in infants and children weighing 5 to <35 kg. However, there are no clinical studies with artemisinin-based combination therapy in infants <5 kg. METH...

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Bibliografische gegevens
Gepubliceerd in:Malar J
Hoofdauteurs: Tiono, Alfred B, Tinto, Halidou, Alao, Maroufou J, Meremikwu, Martin, Tshefu, Antoinette, Ogutu, Bernhards, Ouedraogo, Alphonse, Lingani, Moussa, Cousin, Marc, Lefèvre, Gilbert, Jain, Jay Prakash, Duparc, Stephan, Hamed, Kamal
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407414/
https://ncbi.nlm.nih.gov/pubmed/25886021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12936-015-0682-7
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