Influence of P-Glycoprotein Inhibition or Deficiency at the Blood–Brain Barrier on (18)F-2-Fluoro-2-Deoxy-d-glucose ((18)F-FDG) Brain Kinetics

The fluorinated d-glucose analog (18)F-2-fluoro-2-deoxy-d-glucose ((18)F-FDG) is the most prevalent radiopharmaceutical for positron emission tomography (PET) imaging. P-Glycoprotein’s (P-gp, MDR1, and ABCB1) function in various cancer cell lines and tumors was shown to impact (18)F-FDG incorporatio...

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Dettagli Bibliografici
Pubblicato in:AAPS J
Autori principali: Tournier, Nicolas, Saba, Wadad, Goutal, Sébastien, Gervais, Philippe, Valette, Héric, Scherrmann, Jean-Michel, Bottlaender, Michel, Cisternino, Salvatore
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406966/
https://ncbi.nlm.nih.gov/pubmed/25716150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9739-3
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