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Liquid Chromatography-High Resolution Mass Spectrometry for Peptide Drug Quality Control

A liquid chromatography-high resolution mass spectrometry (LC-HRMS) method was developed using three peptide drugs: salmon calcitonin, bivalirudin, and exenatide as model systems to assess the suitability of this approach for monitoring peptide drug product quality. Calcitonin and its related impuri...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:AAPS J
Hauptverfasser: Zeng, Kui, Geerlof-Vidavisky, Ilan, Gucinski, Ashley, Jiang, Xiaohui, Boyne, Michael T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406950/
https://ncbi.nlm.nih.gov/pubmed/25716148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9730-z
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