The helicase senataxin suppresses the antiviral transcriptional response and controls viral biogenesis

The human helicase senataxin (SETX) is implicated in the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here, we reveal a role for SETX in controlling the antiviral response. Cells depleted for SETX and AOA2 patient-derived SETX-deficient c...

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Bibliografiset tiedot
Julkaisussa:Nat Immunol
Päätekijät: Miller, Matthew S., Rialdi, Alexander, Ho, Jessica Sook Yuin, Tilove, Micah, Martinez-Gil, Luis, Moshkina, Natasha P., Peralta, Zuleyma, Noel, Justine, Melegari, Camilla, Maestre, Ana, Mitsopoulos, Panagiotis, Madrenas, Joaquín, Heinz, Sven, Benner, Chris, Young, John A. T., Feagins, Alicia R., Basler, Christopher, Fernandez-Sesma, Ana, Becherel, Olivier J., Lavin, Martin F., van Bakel, Harm, Marazzi, Ivan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406851/
https://ncbi.nlm.nih.gov/pubmed/25822250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3132
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