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MEK Inhibition in Non-Small Cell Lung Cancer
KRAS mutations are the most common mutations in non-small cell lung cancer (NSCLC) with adenocarcinoma histology. KRAS mutations result in the activation of the RAF-MEK-ERK pathway, and agents that target RAF-MEK-ERK pathways have been investigated in KRAS mutant NSCLC. The two agents furthest in de...
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| Published in: | Lung Cancer |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4406476/ https://ncbi.nlm.nih.gov/pubmed/25257766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2014.09.005 |
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