CYP2B6*6, CYP2B6*18, Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response: population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe

BACKGROUND: Efavirenz (EFV) therapeutic response and toxicity are associated with high inter-individual variability attributed to variation in its pharmacokinetics. Plasma concentrations below 1 μg/ml may result in virologic failure and above 4 μg/ml, may result in central nervous system adverse eff...

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Publicado en:BMC Pharmacol Toxicol
Autores principales: Dhoro, Milcah, Zvada, Simbarashe, Ngara, Bernard, Nhachi, Charles, Kadzirange, Gerald, Chonzi, Prosper, Masimirembwa, Collen
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405819/
https://ncbi.nlm.nih.gov/pubmed/25889207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-015-0004-2
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