Type I Interferon-Mediated Skewing of the Serotonin Synthesis Is Associated with Severe Disease in Systemic Lupus Erythematosus

Serotonin, a highly pro-inflammatory molecule released by activated platelets, is formed by tryptophan. Tryptophan is also needed in the production of kynurenine, a process mediated by the type I interferon (IFN)-regulated rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO). The aim of this study...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Lood, Christian, Tydén, Helena, Gullstrand, Birgitta, Klint, Cecilia, Wenglén, Christina, Nielsen, Christoffer T., Heegaard, Niels H. H., Jönsen, Andreas, Kahn, Robin, Bengtsson, Anders A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405357/
https://ncbi.nlm.nih.gov/pubmed/25897671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125109
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