Glycogen synthase kinase-3 controls IL-10 expression in CD4(+) effector T-cell subsets through epigenetic modification of the IL-10 promoter

The serine/threonine kinase glycogen synthase kinase-3 (GSK3) plays an important role in balancing pro- and anti-inflammatory cytokines. We have examined the role of GSK3 in production of IL-10 by subsets of CD4(+) T helper cells. Treatment of naive murine CD4(+) T cells with GSK3 inhibitors did not...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Hill, Elaine V, Ng, T H Sky, Burton, Bronwen R, Oakley, Charly M, Malik, Karim, Wraith, David C
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Immunomodulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405077/
https://ncbi.nlm.nih.gov/pubmed/25627813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201444661
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