Bone Marrow Stromal Cells Protect Lymphoma B-cells from Rituximab-Induced Apoptosis and Targeting Integrin alfa-4-beta-1 (VLA-4) with Natalizumab can Overcome this Resistance

Rituximab improves the outcome of patients with non-Hodgkin lymphoma, but does not completely eradicate residual B-cell populations in the microenvironment of the bone marrow and lymph nodes. Adhesion to stromal cells can protect B-cells from apoptosis induced by chemotherapy drugs (cell adhesion-me...

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Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Mraz, Marek, Zent, Clive S., Church, Amy K., Jelinek, Diane F., Wu, Xiaosheng, Pospisilova, Sarka, Ansell, Stephen M., Novak, Anne J., Kay, Neil E., Witzig, Thomas E., Nowakowski, Grzegorz S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405035/
https://ncbi.nlm.nih.gov/pubmed/21749361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2011.08794.x
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