Intranasal Vaccination with an Engineered Influenza Virus Expressing the Receptor Binding Subdomain of Botulinum Neurotoxin Provides Protective Immunity Against Botulism and Influenza

Influenza virus is a negative segmented RNA virus without DNA intermediate. This makes it safer as a vaccine delivery vector than most DNA viruses that have potential to integrate their genetic elements into host genomes. In this study, we developed a universal influenza viral vector, expressing the...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Li, Junwei, Diaz-Arévalo, Diana, Chen, Yanping, Zeng, Mingtao
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2015
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404949/
https://ncbi.nlm.nih.gov/pubmed/25954272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00170
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