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Divergent and convergent evolution in metastases suggest treatment strategies based on specific metastatic sites

Background and objective: Systemic therapy for metastatic cancer is currently determined exclusively by the site of tumor origin. Yet, there is increasing evidence that the molecular characteristics of metastases significantly differ from the primary tumor. We define the evolutionary dynamics of met...

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Bibliografske podrobnosti
izdano v:Evol Med Public Health
Main Authors: Cunningham, Jessica J., Brown, Joel S., Vincent, Thomas L., Gatenby, Robert A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404930/
https://ncbi.nlm.nih.gov/pubmed/25794501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emph/eov006
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