The combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophages in situ

Tumor associated macrophages and tumor infiltrating regulatory T cells greatly hamper host-protective antitumor responses. Therefore, we utilized a novel immunomodulator, heat-killed Mycobacterium indicus pranii (Mw), to repolarize TAM and an agonistic GITR antibody (DTA-1) to reduce intratumoral re...

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Опубликовано в: :Oncoimmunology
Главные авторы: Banerjee, Sayantan, Halder, Kuntal, Ghosh, Sweta, Bose, Anamika, Majumdar, Subrata
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2015
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404885/
https://ncbi.nlm.nih.gov/pubmed/25949923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2014.995559
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