Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins

BACKGROUND: Lipopolysaccharide (LPS), also referred to as endotoxin, is the major constituent of the outer leaflet of the outer membrane of virtually all Gram-negative bacteria. The lipid A moiety, which anchors the LPS molecule to the outer membrane, acts as a potent agonist for Toll-like receptor...

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Veröffentlicht in:Microb Cell Fact
Hauptverfasser: Mamat, Uwe, Wilke, Kathleen, Bramhill, David, Schromm, Andra Beate, Lindner, Buko, Kohl, Thomas Andreas, Corchero, José Luis, Villaverde, Antonio, Schaffer, Lana, Head, Steven Robert, Souvignier, Chad, Meredith, Timothy Charles, Woodard, Ronald Wesley
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404585/
https://ncbi.nlm.nih.gov/pubmed/25890161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0241-5
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