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Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained

BACKGROUND: DNA methylation and histone 3 lysine 9 (H3K9) methylation are considered as epigenetic marks that can be inherited through cell divisions. To explore the functional consequences and stability of these modifications, we employed targeted installment of DNA methylation and H3K9 methylation...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Kungulovski, Goran, Nunna, Suneetha, Thomas, Maria, Zanger, Ulrich M, Reinhardt, Richard, Jeltsch, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404288/
https://ncbi.nlm.nih.gov/pubmed/25901185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-015-0002-z
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